Evidence of sympathetic cooling of Na+ ions by a Na MOT in a hybrid trap

A hybrid ion-neutral trap provides an ideal system to study collisional dynamics between ions and neutrals. This system provides a general cooling method that can be applied to optically inaccessible species and can also potentially cool internal degrees of freedom. The long range polarization potentials ($V\propto-\alpha/r^4$) between ions and neutrals result in large scattering cross sections at cold temperatures, making the hybrid trap a favorable system for efficient sympathetic cooling of ions by collisions with neutral atoms. We present experimental evidence of sympathetic cooling in a hybrid trap of \ce{Na+} ions, which are closed shell and therefore do not have a laser induced atomic transition, by equal mass cold Na atoms in a magneto-optical trap (MOT).Comment: 7 figure

Ion-neutral sympathetic cooling in a hybrid linear rf Paul and magneto-optical trap

Long range polarization forces between ions and neutral atoms result in large elastic scattering cross sections, e.g., 10^6 a.u. for Na+ on Na or Ca+ on Na at cold and ultracold temperatures. This suggests that a hybrid ion-neutral trap should offer a general means for significant sympathetic cooling of atomic or molecular ions. We present SIMION 7.0 simulation results concerning the advantages and limitations of sympathetic cooling within a hybrid trap apparatus, consisting of a linear rf Paul trap concentric with a Na magneto-optical trap (MOT). This paper explores the impact of various heating mechanisms on the hybrid system and how parameters related to the MOT, Paul trap, number of ions, and ion species affect the efficiency of the sympathetic cooling

The role of a digital engineering platform in appropriating the creation of new work-related mind-set and organisational discourse in a large multi-national company

YesThis paper reports on a case study involving a strategic and innovative approach to creation of an in-house multifaceted digital engineering platform (the DEP) in overcoming a number of organisational problems at a multinational engineering company. The DEP was to be used strategically for simplifying the operational complexity and to create and appropriate new work-related mind-set and new organisational discourse to achieve homogenous working across the organisation, which is a huge challenge. The need for this system emerged from the need to resolve many organisational services related problems that carried phenomenal amount of processes, health and safety risks and to regulate, and, control the running of engineering project. Research data were collected using a longitudinal case study approach over a period of six months. In order to make sense of how the DEP helped the organisation, the study used certain elements of Extended Structuration Theory as a lens to assess the case study. This research discovered that the DEP succeeded in creating and appropriating work-related mind-set and organisational discourse. It also had real influence on working processes and employees at all levels while encouraging transparency, responsiveness, agility and accountability. It continues to help the organisation to govern, manage and maintain good standard of service but many barriers still remain

Legal linked data ecosystems and the rule of law

This chapter introduces the notions of meta-rule of law and socio-legal ecosystems to both foster and regulate linked democracy. It explores the way of stimulating innovative regulations and building a regulatory quadrant for the rule of law. The chapter summarises briefly (i) the notions of responsive, better and smart regulation; (ii) requirements for legal interchange languages (legal interoperability); (iii) and cognitive ecology approaches. It shows how the protections of the substantive rule of law can be embedded into the semantic languages of the web of data and reflects on the conditions that make possible their enactment and implementation as a socio-legal ecosystem. The chapter suggests in the end a reusable multi-levelled meta-model and four notions of legal validity: positive, composite, formal, and ecological

A Survey of Bayesian Statistical Approaches for Big Data

The modern era is characterised as an era of information or Big Data. This has motivated a huge literature on new methods for extracting information and insights from these data. A natural question is how these approaches differ from those that were available prior to the advent of Big Data. We present a review of published studies that present Bayesian statistical approaches specifically for Big Data and discuss the reported and perceived benefits of these approaches. We conclude by addressing the question of whether focusing only on improving computational algorithms and infrastructure will be enough to face the challenges of Big Data

Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?

Mitochondrial functions include production of energy, activation of programmed cell death, and a number of cell specific tasks, e.g., cell signaling, control of Ca2+ metabolism, and synthesis of a number of important biomolecules. As proper mitochondrial function is critical for normal performance and survival of cells, mitochondrial dysfunction often leads to pathological conditions resulting in various human diseases. Recently mitochondrial dysfunction has been linked to multiple organ failure (MOF) often leading to the death of critical care patients. However, there are two main reasons why this insight did not generate an adequate resonance in clinical settings. First, most data regarding mitochondrial dysfunction in organs susceptible to failure in critical care diseases (liver, kidney, heart, lung, intestine, brain) were collected using animal models. Second, there is no clear therapeutic strategy how acquired mitochondrial dysfunction can be improved. Only the benefit of such therapies will confirm the critical role of mitochondrial dysfunction in clinical settings. Here we summarized data on mitochondrial dysfunction obtained in diverse experimental systems, which are related to conditions seen in intensive care unit (ICU) patients. Particular attention is given to mechanisms that cause cell death and organ dysfunction and to prospective therapeutic strategies, directed to recover mitochondrial function. Collectively the data discussed in this review suggest that appropriate diagnosis and specific treatment of mitochondrial dysfunction in ICU patients may significantly improve the clinical outcome